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Features and Benefits 2020-06-15 · See product citations (192) Alternate Names: Rapamycin is also known as mTOR Inhibitor I. Application: Rapamycin acts as an allosteric inhibitor of mTOR and inhibits FRAP autophosphorylation, which leads to activation of the p70/85 S6 kinase. CAS Number: 53123-88-9. Purity: ≥98%. Rapamycin as used for this purpose must inhibit both mTORC1 and mTORC2. This requires high continuous blood levels.
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Sirolimus(Rapamune) generic is an immunosuppressant, prescribed for preventing rejection of kidney transplants either alone or with other medications. It works by suppressing the body's immune system. Rapamycin significantly improved heart function —in particular, left ventricular function during the 10 week study, and that the improvement was greatest in those patients with more severe heart disease.
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Rapamycin (Sirolimus, AY 22989, NSC-2260804) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells. Targets. mTOR [1] (HEK293 cells) ~0.1 nM.
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